Sunday, January 20, 2013

Stupidity in Science and Preparations for Research


I had the opportunity to read three articles written Martin A. Schwartz and Jonathan W. Yewdell, two of which were written from the latter. The articles delt with the nature of what science is, which I am fully aware of, but in a different light. In Schwartz’s short article, he mentions that it is a good idea if you “feel stupid” doing science. He did not mean that as an insult; what he meant to say was that in science, we never really know everything about nature. Through research, some of our hypotheses are shown to be wrong and our experiments may fail terribly. Often times, we can get different results that were not expected to arise from the data. These possibilities that come from the research experience can overwhelm us and we tend to feel very frustrated. Unfortunately, this frustration can lead to discouragement to continue doing research. Schwartz recounts one event in which one of his friends gave up on a science career to pursue law because she felt “stupid” in grad school. The main point that Schwartz tried to get across is that we are expected to feel as if we know nothing of our research outcomes. That is what makes research… well, research! There will be moments when we will enter into unknown territory. We will come across difficulty in trying to understand outcomes that we thought should have “never happened”. Schwartz also makes a point that during high school and college, we are used to having to do science with the guidance of a teacher. In grad school, you are all on your own, except with some advice from your mentor here and there. During grad school, it’s not just following orders in doing an experiment. We have to fully understand it and make it our own. I can relate to this feeling of “stupidity” because I did not have any previous experience with working on my own. It is also a similar in my experience in observing what my data is and how I must deal with unexpected results. For example, despite the fact that I have recreated the nitration of toluene trials from previous research, I have not obtained a yield of greater than or equal to 92%. The results upset me because it compels me to look into how I am losing so much of my product. Despite the fact that I have been trying to be careful in my techniques, I still cannot obtain a high yield. I refuse to give up in my project. These experiences prepared me for Jonathan W. Yewdell’s guide of succeeding in research.

After reading his two articles on what to do in order to succeed in research, I felt a bit overwhelmed at how many variables are involved that influence the way research is done. Granted, I am already aware of the difficulty in research that one is subjected to, but in this case a specific example was used: biomedical research. Some of the helpful tips that I read on the article made sense: the importance of choosing a good quality graduate program, choosing a good mentor, and an evaluation of what your talents and dedications are in life that will help you excel in research. He then went further into detail about how to choose your project and how to formulate your own questions. I remember when I had to figure out what to ask for the beginning of my thesis. Since I chose the thesis, my question and hypothesis have been constantly changed. With the help of my mentor, it was decided that one type of compound will be tested instead of whole wide range of compounds. Since my sample size is smaller, it is a lot easier to control. Yewdell argues that teachers should introduce students who want to go into research the basic principles being involved in it. I agree with that and to his support of it, the fact that I am taking a research class proves his point that it can be of extreme benefit to have a taste of what graduate school might be like. Reading these articles compels me to prepare heavily for a future research career in my life. It does not frustrate me and it does not discourage me to look into it. I’m glad to know that there is no shame in feeling like an idiot during research, since it is part of the scientific process. I look forward to feel stupid… in a smart way when I continue on my education. Hopefully, other individuals would take into consideration what they read in these articles so that they can know what they are getting themselves into.

 

 

References

1)      Schartz, Martin A. “The Importance of Stupidity in Science”. Journal of Cell Science 121, 1771 2008

2)      Yewdell, Jonathan W. “How to succeed in Science: a concise guide for young biomedical scientists. Part I&II”. Molecular Cell Biology 2008

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